Endocrine Abstracts

Introduction: Pituitary adenomas in people over 65 represent less than 10% of all pituitary adenomas, 80% of which are non-functional. Somatotropic adenomas remain very rare. The interest of our study is to describe the clinical, paraclinical and therapeutic profile of cases of senile acromegaly.Patients and methods: This is a retrospective study of four senile acromegaly patients followed in our endocrinology’s department.Res...

Long fasting in patients with adrenal insufficiency could cause hypotension, dehydration or hypoglycaemia. No studies evaluated these risks and there is no recommendations about fasting for these patients. The aim of our study was to evaluate the potential risks of fasting during the month of Ramadan in patients with adrenal insufficiency.Subjects and methods: It is a cross sectional study that concerned 125 subjects (97 women and 28 men, mean age=47.8 y...

Introduction: Sheehan syndrome represents a rare cause of hypopituitarism. It results from postpartum ischemic necrosis of the pituitary gland. Data evaluating the quality of life in women with Sheehan syndrome are scarce. The aim of this study was to assess the quality of life in patients with Sheehan syndrome and to determine its associated factors.Methods: A cross-sectional study including women with Sheehan syndrome was conducted in the department of...

Introduction: Insulin allergy is a clinical challenge in the management of type 1 diabetes mellitus since there is no other therapeutic alternative. The specific cause of insulin allergy can be related to insulin itself or to additives including zinc, protamine and meta-cresol. The manifestations range from localized reactions to systemic severe anaphylaxis. We here present the case of a generalized allergy to insulin excipient meta-cresol, in a type 1 diabetic patient success...

Plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenomas. Functioning ACTH-GH pituitary adenomas constitute an extremely rare entity. Most patients present a clinically manifested acromegaly and subclinical Cushing’s disease. We present the case of a 14 years old female who referred to the endocrinology department for inaugural diabetic ketosis. She had a six-month history of amenorrhea and headaches. On examination, she had facial dysmporph...

Introduction: Hemochromatosis is associated with iron overload that is responsible of iron deposit causing multiple organ dysfunctions which affects especially endocrine glands.Methods: We report four cases of pituitary hemochromatosis responsible of endocrine dysfunction. Results: Three women and one man were included, aged respectively 28, 19, 26 and 35 years old. These patients were suffering from ß-thalassemia and treated ...

Introduction: Hypothyroidism is a common endocrine disease with reduced systemic metabolism and its treatment consists on hormonal supplementation. However, despite concurrent replacement therapy with high doses of L-thyroxin, some patients might be seen with clinical and biochemical evidence of hypothyroidism. We report a case of persistent hypothyroidism on high dose of levothyroxin.Case presentation: It was a 41-year-old female, with a history of recu...

Introduction: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited syndrome predisposing to a variety of highly vascularised tumors in different organs. Although bilateral pheochromocytoma was reported in patient with VHL disease, the coexistence of primary hyperparathyroidism is not a common condition. Herein we report a case of a primary hyperparathyroidism secondary to an ectopic secretion of intact parathyroid hormone (PTH) in a patient with VHL disease and b...

Introduction: Osteogenesis imperfecta also known as Lobstein’s disease (LD) is a rare disorder of type 1 collagen characterized by an increased susceptibility to bone fractures. Its coexistencewith primary hyperparathyroidism (PHP) was rarely described. Herein we report a new case of a primary hyperparathyroidismin a patient with a history of Lobstein’s disease.Observation: A 35-year-old woman was referred to our departmentfor hypercalcemia. He...

Background: Thyroid nodules are the most common thyroid disease. In the majority of cases, they are benign. However, 5 to 15% of nodules are cancer. The aim of our study was to determine the clinical and biological predictive factors of malignancy in thyroid nodules.Methods: We performed a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital over 18 year old period (2000–2018). All the...